ParkinsonCanadaV1, Main, Exploration, bibRecord, 001900

WALKING IN CIRCLES: NAVIGATION DEFICITS FROM PARKINSON'S DISEASE BUT NOT FROM CEREBELLAR ATAXIA

Identifieur interne : 001900 ( Main/Exploration ); précédent : 001899; suivant : 001901

WALKING IN CIRCLES: NAVIGATION DEFICITS FROM PARKINSON'S DISEASE BUT NOT FROM CEREBELLAR ATAXIA

Auteurs : C. Paquette [États-Unis] ; E. Franzen [États-Unis, Suède] ; G. M. Jones [Canada] ; F. B. Horak [États-Unis]

Source :

Neuroscience [ 0306-4522 ] ; 2011.

RBID : Pascal:11-0439619

Descripteurs français

Pascal (Inist)
- Marche à pied, Cervelet, Lévodopa, Maladie de Parkinson.

English descriptors

KwdEn :
- Cerebellum, Levodopa, Parkinson disease, Walking.

Abstract

Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), eight subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156363

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), eight subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

WALKING IN CIRCLES: NAVIGATION DEFICITS FROM PARKINSON'S DISEASE BUT NOT FROM CEREBELLAR ATAXIA

WALKING IN CIRCLES: NAVIGATION DEFICITS FROM PARKINSON'S DISEASE BUT NOT FROM CEREBELLAR ATAXIA

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.